11/19/2022 0 Comments Design doll 3.9.8.9![]() ![]() As a novel finding it was shown that risks for siblings were higher than those for offspring of affected parents. Familial standardized incidence ratios (SIRs) were determined for offspring when parents or sibling were diagnosed with colon or rectal cancer. We show one application of the Database in the study of familial risks in colorectal adenocarcinoma, with defined age-group and anatomic site specific analyses. Compared to previous versions, only 6.0% of deceased offspring with a cancer diagnosis lack any parental information. Cancer cases were retrieved from the Swedish Cancer Registry from 1958-2002, including over 1.2 million first and multiple primary cancers and in situ tumours. This update included all Swedes born in 1932 and later (offspring) with their biological parents, a total of 10.5 million individuals. In the present paper we describe some main features of version VI of this Database, assembled in 2004. Our judgment is that the observed gradient in women points to a role for industrial air pollution.The Swedish Family-Cancer Database has been used for almost 10 years in the study of familial risks at all common sites. Explanations for differences between men and women may include gender-specific occupational experiences and smoking patterns. The association between raised lung cancer mortality and proximity to industry in women under 75 years of age could not be explained by smoking, occupation, socioeconomic factors, or artifact. Overall rates in Teesside were higher than Sunderland rates for women aged 0-64 years (SMR = 287 vs. In women 0-64 years of age, stronger gradients in lung cancer mortality corresponded with proximity to industry across zones A, B, and C (SMR = 393, 251, 242, respectively). ![]() For men, a weak gradient corresponding with proximity to industry at younger ages reversed at older ages. Mortality from lung cancer was well above national levels in all zones. Standardized mortality ratios (SMR) for lung cancer and cancers other than lung (ICD-9 140-239, excluding 162), and sex ratios were calculated. Housing estates in Teesside were selected based on socioeconomic criteria and distinguished by proximity to steel and chemical industries they were grouped into three zones: near (A), intermediate (B), and farther (C), with a single zone in Sunderland. Analysis was based on two conurbations in England, Teesside and Sunderland. Mortality data, census data, a postal survey of living circumstances, historic and contemporary data on air quality and a historic land-use survey were used. ![]() This study assesses whether deprived populations living close to industry experience greater mortality from lung cancer than populations with comparable socioeconomic characteristics living farther away. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |